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KMID : 0880220140520050441
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Journal of Microbiology
2014 Volume.52 No. 5 p.441 ~ p.443
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Antifungal Chitinase against Human Pathogenic Yeasts from Coprinellus congregatus
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Yoo Yee-Un
Choi Hyoung-T.
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Abstract
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The inky cap, Coprinellus congregatus, produces mushrooms which become autolyzed rapidly to generate black liquid droplets, in which no cell wall is detected by microscopy. A chitinase (Chi2) which is synthesized during the autolytic phase of C. congregatus inhibits the growths of Candida al-bicans and Cryptococcus neoformans up to 10% at the con-centration of 10 μg/ml, about 50% at concentration of 20 μg/ml, and up to 95% at the concentration of 70 μg/ml. Upon treatment these yeast cells are observed to be severely de-formed, with the formation of large holes in the cell wall. The two yeast species show no growth inhibition at the concen-tration of 5 μg/ml, which means the minimum inhibitory concentrations for both yeast species are 10 μg/ml under these experimental conditions.
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KEYWORD
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antifungal chitinase, Coprinellus congregatus, hu-man pathogenic yeasts
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